长期饮酒与首次症状性癫痫发作
Chronic alcohol use and first symptomatic epileptic seizures.
作者信息
Leone M, Tonini C, Bogliun G, Monaco F, Mutani R, Bottacchi E, Gambaro P, Rocci E, Tassinari T, Cavestro C, Beghi E
机构信息
Clinica Neurologica, Università A. Avogadro, Novara.
出版信息
J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):495-9. doi: 10.1136/jnnp.73.5.495.
OBJECTIVE
To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure.
METHODS
Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (+/-5 years), and underlying pathology.
RESULTS
The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for >100 g/day.
CONCLUSIONS
We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.
目的
确定慢性酒精中毒和饮酒是否为首次出现症状性癫痫发作的危险因素。
方法
对293例首次出现因头部外伤、中风或脑肿瘤导致的症状性发作（急性或既往发作）的患者（160例男性，133例女性）进行多中心病例对照研究，根据中心、性别、年龄（±5岁）和潜在病理情况与444例医院对照进行匹配。
结果
男性酗酒者首次发作的风险不高于非酗酒者（比值比1.2，95%置信区间0.4至3.2），女性也是如此（1.5，0.1至54.4）。平均每日纯酒精摄入量为1 - 25克时，比值比（男女合计）为1.2（0.8至1.7）；26 - 50克时为0.9（0.5至1.5）；51 - 100克时为1.6（0.8至3.0）；超过100克时为1.4（0.5至3.5）。
结论
我们没有发现饮酒或酗酒与首次症状性发作之间存在关联的证据。
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