饮酒是首次全身性强直阵挛性发作的一个风险因素。酒精与癫痫（ALC.E.）研究小组。

Alcohol use is a risk factor for a first generalized tonic-clonic seizure. The ALC.E. (Alcohol and Epilepsy) Study Group.

作者信息

Leone M, Bottacchi E, Beghi E, Morgando E, Mutani R, Amedeo G, Cremo R, Gianelli M, Ravagli Ceroni L

机构信息

Divisione Universitaria di Neurologia, Facoltà di Medicina e Chirurgiadi Novara, Università di Torino, Italy.

出版信息

Neurology. 1997 Mar;48(3):614-20. doi: 10.1212/wnl.48.3.614.

DOI:10.1212/wnl.48.3.614

PMID:9065535

Abstract

We performed a multicenter case-control study to estimate whether chronic alcoholism and alcohol consumption are risk factors for developing a first generalized tonic-clonic seizure (GTCS). We studied 237 first-seizure patients (158 men, 79 women) matched to 474 hospital controls for center, sex, age (+/-5 years), and weekday of the seizure. The risk of first GTCS in alcoholics was greater than in non-alcoholics for men (odds ratio, 6.8; 95% confidence limits, 3.6-13.0) and women (6.8, 1.6-32.6). The odds ratio (both sexes) was 1.2 (0.8-1.8) for an average daily intake of absolute alcohol of 1 to 25 g/day and rose with the amount of alcohol consumed daily: 1.3 (0.8-2.1) for 26 to 50 g/day, 3.0 (1.7-5.4) for 51 to 100 g/day, 7.9 (2.9-21.9) for 101 to 200 g/day, and 16.6 (1.9-373.4) for >200 g/day. Our study provides evidence of a powerful association between alcohol use, alcoholism, and the first GTCS.

摘要

我们开展了一项多中心病例对照研究，以评估慢性酒精中毒和饮酒是否为首次发生全面性强直阵挛发作（GTCS）的风险因素。我们研究了237例首次发作的患者（158例男性，79例女性），并按照中心、性别、年龄（±5岁）和发作的工作日，将其与474例医院对照者进行匹配。男性酗酒者首次发生GTCS的风险高于非酗酒者（比值比为6.8；95%置信区间为3.6 - 13.0），女性也是如此（6.8，1.6 - 32.6）。每日纯酒精平均摄入量为1至25克/天时，（男女合计）比值比为1.2（0.8 - 1.8），且随着每日饮酒量的增加而升高：26至50克/天时为1.3（0.8 - 2.1），51至100克/天时为3.0（1.7 - 5.4），101至200克/天时为7.9（2.9 - 21.9），超过200克/天时为16.6（1.9 - 373.4）。我们的研究提供了饮酒、酒精中毒与首次GTCS之间存在强关联的证据。