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血小板黏附性与癌细胞黏附性:一项对比研究。

Platelet adhesiveness and cancer cell stickiness: a comparative study.

作者信息

Jacobi E

出版信息

Pflugers Arch. 1975 Dec 19;361(1):65-8. doi: 10.1007/BF00587341.

DOI:10.1007/BF00587341
PMID:1239743
Abstract

Comparing platelet adhesiveness and cancer cell stickiness under the conditions of the so-called Fibre test showed that: 1. Platelets aggregate in the first few seconds only, whereas Yoshida sarcoma cells accumulate continuously. 2. Platelets show a characteristic velocity profile. Platelet adhesiveness shows a maximum at a velocity of 7 cm/sec. Yoshida sarcoma cells adhere better at low flow velocity. 3. An experimentally induced electric current (streaming electric current) of ca. 40 mV augments platelet adhesiveness to twice the basal value, whereas Yoshida sarcoma cells remain uninfluenced by the current. These results suggest an interaction between platelets and vessel wall, whereas Yoshida sarcoma cells adhere passively.

摘要

在所谓的纤维试验条件下比较血小板黏附性和癌细胞黏附性,结果显示:1. 血小板仅在最初几秒内聚集,而吉田肉瘤细胞持续积累。2. 血小板呈现出特征性的速度分布。血小板黏附性在7厘米/秒的速度时达到最大值。吉田肉瘤细胞在低流速下黏附性更好。3. 约40毫伏的实验诱导电流(流动电流)可使血小板黏附性增强至基础值的两倍,而吉田肉瘤细胞不受该电流影响。这些结果表明血小板与血管壁之间存在相互作用,而吉田肉瘤细胞是被动黏附。

相似文献

1
Platelet adhesiveness and cancer cell stickiness: a comparative study.血小板黏附性与癌细胞黏附性:一项对比研究。
Pflugers Arch. 1975 Dec 19;361(1):65-8. doi: 10.1007/BF00587341.
2
The possible role of platelets as trigger in intravascular coagulation associated with acute hyperparathyroidism.血小板在与急性甲状旁腺功能亢进相关的血管内凝血中作为触发因素的可能作用。
Acta Univ Carol Med Monogr. 1972;53:427-32.
3
A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.一种灌注室,用于研究流动血液中血小板与人体血管壁细胞、其细胞外基质及纯化成分之间的相互作用。
J Lab Clin Med. 1983 Oct;102(4):522-35.
4
Inhibition of cancer cell stickiness by the blocking of platelet aggregation.通过阻断血小板聚集来抑制癌细胞黏附性。
S Afr Med J. 1974 Mar 30;48(15):621-7.
5
Platelet adhesion.血小板黏附
Prog Hemost Thromb. 1984;7:211-88.
6
[Von Willebrand factor and platelet adhesion to the subendothelium of the vascular wall].[血管性血友病因子与血小板对血管壁内皮下层的黏附]
Nouv Rev Fr Hematol (1978). 1982;24(3):145-51.
7
Preparation for disseminated intravascular coagulation by Yoshida sarcoma in rats.大鼠吉田肉瘤所致弥散性血管内凝血的制备
Cancer. 1978 Apr;41(4):1635-41. doi: 10.1002/1097-0142(197804)41:4<1635::aid-cncr2820410455>3.0.co;2-m.
8
Platelet deposition on subendothelium exposed to flowing blood: mathematical analysis of physical parameters.
Trans Am Soc Artif Intern Organs. 1975;21:593-601.
9
Effect of aspirin on thrombin-induced adherence of platelets to cultured cells from the blood vessel wall.阿司匹林对凝血酶诱导的血小板与血管壁培养细胞黏附的影响。
J Clin Invest. 1978 Oct;62(4):847-56. doi: 10.1172/JCI109197.
10
The influence of Yoshida sarcoma, -aminocaproic acid and sintrom on the blood clotting system in rats.
Arch Immunol Ther Exp (Warsz). 1971;19(4):515-22.

本文引用的文献

1
[Velocity-dependent reciprocity between thrombocytes and various surfaces].[血小板与各种表面之间的速度依赖性互易性]
Klin Wochenschr. 1970 Apr 1;48(7):442-3. doi: 10.1007/BF01487018.
2
[In-vitro method for the determination of platelet adhesiveness].[血小板黏附性测定的体外方法]
Thromb Diath Haemorrh. 1971 Aug 31;26(1):192-202.
3
The role of blood platelets in experimental metastases.血小板在实验性转移中的作用。
Br J Cancer. 1973 Nov;28(5):429-35. doi: 10.1038/bjc.1973.168.
4
Arvin-induced hypofibrinogenemia and metastasis formation from blood-borne cancer cells.阿文诱导的低纤维蛋白原血症与血源性癌细胞转移的形成。
Johns Hopkins Med J. 1973 Oct;133(4):207-13.