酚妥拉明对大鼠5-羟色胺中枢活性的影响。
The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat.
作者信息
Kleinrok Z, Jagiello-Wójtowicz E, Sieklucka M
出版信息
Pol J Pharmacol Pharm. 1975 Oct;27(Suppl):99-106.
PHENT (20 and 100 mug ivc) affects the central action of 5-HT (0-1, 25 and 250 mug) in rats which shows itself in potentiation of 5-HT-induced inhibition of spontaneous locomotor and exploratory activities and in the prolongation of hexobarbital sleeping time. In case of postamphetamine hyperactivity and body temperature, 5-HT acts antagonistically to a lower PHENT dose and synergistically to a higher dose of this compound. No affect of 5-HT on a slight antistereotypy action of PHENT has been stated. Neither compound affects electrical seizures.
芬太尼（静脉注射20和100微克）影响大鼠体内5-羟色胺（0 - 1、25和250微克）的中枢作用，表现为增强5-羟色胺诱导的对自发运动和探索活动的抑制作用，并延长己巴比妥睡眠时间。在苯丙胺引起的多动和体温升高情况下，5-羟色胺对较低剂量的芬太尼起拮抗作用，对较高剂量的该化合物起协同作用。未提及5-羟色胺对芬太尼轻微的抗刻板行为作用有影响。两种化合物均不影响电惊厥。
Zotero 插件