Loh T T, Juggi J S
Proc Soc Exp Biol Med. 1975 Nov;150(2):537-40. doi: 10.3181/00379727-150-39073.
The changes in the haematological parameters and iron metabolism in rats with fatty livers after they had been fed with 20% alcohol and normal standard diet for a period of 12 months were studied. The haematocrit, haemoglobulin concentration and erythrocyte count were within the normal range. The erythropoietic rate was elevated, probably as the result of the shortened life-span of the erythrocytes. The rate of iron absorption in the alcoholic rat did not vary. The iron stores in the spleen and small intestine were, however, markedly increased. The ferrokinetic study shows that the alcoholic rat had a lower plasma iron turnover rate. In view of the elevated erythropoiesis the implication of this finding is difficult to interpret when the efflux of plasma iron to the unspecific soft tissues is not available.
研究了用20%酒精和正常标准饮食喂养12个月的脂肪肝大鼠血液学参数和铁代谢的变化。血细胞比容、血红蛋白浓度和红细胞计数均在正常范围内。红细胞生成率升高，可能是红细胞寿命缩短的结果。酒精性大鼠的铁吸收速率没有变化。然而，脾脏和小肠中的铁储存明显增加。铁动力学研究表明，酒精性大鼠的血浆铁周转率较低。鉴于红细胞生成增加，当血浆铁向非特异性软组织的流出不可用时，这一发现的意义难以解释。
