吲哚美辛对早产和成熟新生山羊肺血管对缺氧反应的影响。

The effects of indomethacin on the pulmonary vascular response to hypoxia in the premature and mature newborn goat.

作者信息

Tyler T, Wallis R, Leffler C, Cassin S

出版信息

Proc Soc Exp Biol Med. 1975 Dec;150(3):695-8. doi: 10.3181/00379727-150-39108.

Abstract

The effects of indomethacin on the pulmonary circulation and the response of the circulation to hypoxia were investigated in premature and mature newborns using an isolated perfusion technique on otherwise intact left lungs in situ. There was an increase in pulmonary vascular resistance and augmentation of the increase in pulmonary vascular resistance during hypoxia following indomethacin. These effects were greater in the premature than in the mature newborn. Indomethacin effectively removes a dilator influence on the pulmonary circulation. The results are consistent with the concept that prostaglandins are important in regulating pulmonary vascular resistance.

摘要

采用原位完整左肺的离体灌注技术，研究了吲哚美辛对早产和足月新生儿肺循环的影响以及循环系统对缺氧的反应。吲哚美辛使肺血管阻力增加，且缺氧时肺血管阻力增加的幅度更大。这些效应在早产儿中比足月儿更明显。吲哚美辛有效消除了对肺循环的扩张作用。这些结果与前列腺素在调节肺血管阻力中起重要作用的观点一致。