The effect of endoscopic injection sclerotherapy on portal blood flow and liver function.

作者信息

Sugimoto Kazushi, Shiraki Katsuya, Murata Kazumoto, Ito Takeshi, Ohmori Shigeru, Sakai Takahisa, Yamanaka Takenari, Takase Koujiro, Nakano Takeshi, Nakanishi Shigeo

机构信息

First Department of Internal Medicine, Mie University School of Medicine, 2-174, Edobashi, Tsu, Mie, Japan.

出版信息

Hepatogastroenterology. 2002 Nov-Dec;49(48):1587-90.

PMID:12397742

Abstract

BACKGROUND/AIMS: It is still controversial whether endoscopic injection sclerotherapy can affect portal blood flow and liver function. To clarify this issue, we investigated the change in portal blood flow velocity and the relationship between liver function and portal blood flow after sclerotherapy.

METHODOLOGY

Ten liver cirrhosis patients with F2 esophageal varices were enrolled in this study. All patients underwent sclerotherapy until all varices were eradicated. Portal blood flow velocity was measured using Doppler ultrasonography. The changes in laboratory parameters and the portal flow velocity were analyzed in each patient.

RESULTS

Total mean portal blood flow velocity was changed from 7.5 +/- 5.3 cm/s to 10.3 +/- 3.5 cm/s by sclerotherapy. Six of ten cases had increase in portal blood flow velocity. Among them, 5 cases demonstrated improvement in serum albumin and total cholesterol level 3 months after sclerotherapy.

CONCLUSIONS

Prophylactic endoscopic injection sclerotherapy among patients with early liver cirrhosis can improve liver function by increasing the portal blood flow.

摘要