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甲喹酮：小鼠的耐受性和身体依赖性

Methaqualone: tolerance and physical dependence in mice.

作者信息

Alpern H P, Greer C A, Stripling J S, Collins A C, Olson R K

出版信息

Psychopharmacologia. 1975 Nov 21;44(3):303-5. doi: 10.1007/BF00428912.

DOI:10.1007/BF00428912
PMID:1239784
Abstract

Tolerance and physical dependence was produced in C57Bl/6 male mice that had been exposed, for 36 days, to methaqualone in food pellets via an automated system. Tolerance was revealed in the reduction of sleep-times following intraperitoneal injection of methaqualone. Physical dependence was manifested as an alteration in neural sensitivity to flurothyl-induced convulsions.

摘要

通过自动化系统，让C57Bl/6雄性小鼠在36天内食用含甲喹酮的食丸，从而使其产生耐受性和身体依赖性。腹腔注射甲喹酮后睡眠时间缩短表明产生了耐受性。身体依赖性表现为神经对氟烷诱导惊厥的敏感性发生改变。

相似文献

1
Methaqualone: tolerance and physical dependence in mice.甲喹酮：小鼠的耐受性和身体依赖性
Psychopharmacologia. 1975 Nov 21;44(3):303-5. doi: 10.1007/BF00428912.
2
Increased CNS sensitivity to flurothyl as a measure of physical dependence in mice following morphine, phenobarbital, and ethanol treatment.氟烷作为衡量吗啡、苯巴比妥和乙醇处理后小鼠身体依赖性的指标，其对中枢神经系统的敏感性增加。
Life Sci. 1976 Jun 15;18(12):1375-82. doi: 10.1016/0024-3205(76)90353-2.
3
The effects of methaqualone on the seizure susceptibility of mice.甲喹酮对小鼠癫痫易感性的影响。
Psychopharmacology (Berl). 1977 Aug 31;54(1):45-9. doi: 10.1007/BF00426540.
4
An experimental evaluation of dependence liability of methaqualone diphenhydramine (combination) and methaqualone in rats.甲喹酮-苯海拉明（复方）和甲喹酮对大鼠依赖性的实验评估
Psychopharmacology (Berl). 1980 Feb;67(2):203-7. doi: 10.1007/BF00431978.
5
An experimental investigation of dependence liability of methaqualone in rats.甲喹酮对大鼠依赖性的实验研究。
Psychopharmacologia. 1974 Mar 9;35(4):327-34. doi: 10.1007/BF00429223.
6
Effects of dixyrazine and methaqualone on the sleep pattern in normal man.
Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):227-31. doi: 10.1007/BF00567120.
7
The effects of methaqualone on the temperature regulation of mice.
Res Commun Chem Pathol Pharmacol. 1977 May;17(1):41-52.
8
Sex differences in physical dependence on methaqualone in the rat.大鼠对甲喹酮身体依赖性的性别差异。
Pharmacol Biochem Behav. 1988 Jun;30(2):483-8. doi: 10.1016/0091-3057(88)90484-4.
9
Cross-physical dependence of several drugs in methaqualone-dependent rats.甲喹酮依赖大鼠中几种药物的交叉身体依赖性。
Jpn J Pharmacol. 1988 Apr;46(4):403-10. doi: 10.1254/jjp.46.403.
10
Sleep and hypnotics: further experiments.睡眠与催眠药：进一步的实验
Br Med J. 1970 Aug 8;3(5718):310-3. doi: 10.1136/bmj.3.5718.310.

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The effects of methaqualone on the seizure susceptibility of mice.甲喹酮对小鼠癫痫易感性的影响。
Psychopharmacology (Berl). 1977 Aug 31;54(1):45-9. doi: 10.1007/BF00426540.
3
Maturational changes related to dopamine in the effects of d-amphetamine, cocaine, nicotine, and strychnine on seizure susceptibility.与多巴胺相关的成熟变化在右旋苯丙胺、可卡因、尼古丁和士的宁对癫痫易感性的影响中所起的作用。

本文引用的文献

1
Methaqualone addiction and delirium tremens.甲喹酮成瘾与震颤谵妄
Br Med J. 1967 Jul 8;3(5557):92-3. doi: 10.1136/bmj.3.5557.92.
2
Barbiturate withdrawal in white rats.白鼠的巴比妥酸盐戒断反应
Int J Neuropharmacol. 1966 Jan;5(1):103-7. doi: 10.1016/0028-3908(66)90055-4.
3
The rapid development of physical dependence on barbiturates.对巴比妥类药物身体依赖性的迅速发展。
Psychopharmacology (Berl). 1979 Sep;64(3):255-60. doi: 10.1007/BF00427507.
J Pharmacol Exp Ther. 1965 Oct;150(1):140-5.
4
Clinical and experimental aspects of barbiturate withdrawal convulsions.巴比妥类药物戒断性惊厥的临床与实验研究
Epilepsia. 1967 Mar;8(1):21-30. doi: 10.1111/j.1528-1157.1967.tb03816.x.
5
Studies on the pharmacology of methaqualone: induction of mammalian hepatic delta-aminolevulinic acid synthetase.甲喹酮药理学研究：哺乳动物肝脏δ-氨基乙酰丙酸合成酶的诱导作用。
Proc Soc Exp Biol Med. 1974 Jun;146(2):367-72. doi: 10.3181/00379727-146-38106.
6
An experimental investigation of dependence liability of methaqualone in rats.甲喹酮对大鼠依赖性的实验研究。
Psychopharmacologia. 1974 Mar 9;35(4):327-34. doi: 10.1007/BF00429223.
7
Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats.
Psychopharmacologia. 1974 Feb 27;35(3):243-7. doi: 10.1007/BF00437753.
8
Methaqualone abuse, the quiet epidemic.甲喹酮滥用，这一悄然蔓延的流行病。
JAMA. 1973 Jun 11;224(11):1512-4.
9
Methaqualone abuse. "Luding out".
JAMA. 1973 Jun 11;224(11):1505-9.
10
Nonmedical use of methaqualone.甲喹酮的非医疗用途。
Arch Gen Psychiatry. 1973 May;28(5):627-31. doi: 10.1001/archpsyc.1973.01750350011002.