发情后期和去卵巢牛注射前列腺素F2α后的血液促黄体生成素

Blood LH after PGF2alpha in diestrous and ovariectomized cattle.

作者信息

Hafs H D, Louis T M, Stellflug J N, Convey E M, Britt J H

出版信息

Prostaglandins. 1975 Dec;10(6):1001-9. doi: 10.1016/s0090-6980(75)80047-5.

Abstract

Two experiments were conducted to determine whether the increased serum LH which occurs within 12 hr after a luteolytic dose of PGF2alpha is dependent upon changes in progesterone or estradiol secretion. In the first experiment, exogenous progesterone abolished the increase in serum LH caused by a subcutaneous injection of 25 mg PGF2alpha in diestrous heifers, but not in ovariectomized heifers. In the second experiment, progesterone pessaries were removed at 6 hr after a subcutaneous injection of 25 mg PGF2alpha. LH remained at pre-PGF2alpha values while the pessaries were in place, but began to increase within 1 hr after they were removed. Blood estradiol also remained at pre-PGF2alpha values until the pessaries were removed, and began to increase at 2 hr after pessary removal. We conclude that the increase in serum LH within 12 hr after PGF2alpha treatment in diestrous cattle is dependent upon withdrawal of progesterone; it is not due to increased serum estradiol.

摘要

进行了两项实验，以确定在给予溶黄体剂量的前列腺素F2α（PGF2α）后12小时内血清促黄体生成素（LH）升高是否依赖于孕酮或雌二醇分泌的变化。在第一个实验中，外源性孕酮消除了在间情期小母牛皮下注射25毫克PGF2α所引起的血清LH升高，但在去卵巢小母牛中未消除。在第二个实验中，在皮下注射25毫克PGF2α后6小时取出孕酮阴道栓。在阴道栓放置期间，LH保持在注射PGF2α前的水平，但在取出后1小时内开始升高。血液中的雌二醇在阴道栓取出前也保持在注射PGF2α前的水平，并在取出阴道栓后2小时开始升高。我们得出结论，在间情期母牛中，PGF2α治疗后12小时内血清LH升高依赖于孕酮的撤离；而非血清雌二醇升高所致。