Chichinadze N K, Begiashvili T V, Gachechiladze L F
Arkh Anat Gistol Embriol. 1975 Nov;69(11):33-9.
In order to reveal possible stimulation of growth of the germinal epithelium of the rat's injured testicle the animals were injected follicle-stimulating and luteinizing hormones and their mixture as well as homogenate of fertilized egg-cells during two weeks. Changes of neurosecretion in large-cell nuclei of the anterior hypothalamus, cellular set in the adenohypophysis and the condition of the germinal epithelium in the gonad under study were investigated. Identical phenomena of reduction (having quantitative distinctions) took place due to effects of exogeneous honadotropins in neurosecretory nuclei and the adenohypophysis. In testicular tubules there occurred pronounced proliferation of the germinal epithelium, but spermatogenesis was absent. Egg-cell homogenate failed to cause changes in neurosecretion and adenohypophysis but resulted in completing the developmental cycle of the germinal epithelium with mature spermatozoa. The effect of gonadotropins upon the system hypothalamus-hypophysis is explained by feed-back mechanism, and the absence of spermatogenesis--by the lack of androgens. The rsults of egg-cell homogenate effects should be associated with local stimulating effects of DNA of the dividing egg-cell.
为了揭示对大鼠受伤睾丸生精上皮生长可能的刺激作用，在两周时间内给动物注射促卵泡激素、促黄体生成素及其混合物以及受精卵细胞匀浆。研究了下丘脑前部大细胞核中的神经分泌变化、腺垂体中的细胞群以及所研究性腺中生精上皮的状况。由于外源性促性腺激素对神经分泌核和腺垂体的作用，出现了相同的减少现象（存在数量差异）。在睾丸小管中生精上皮出现明显增殖，但无精子发生。卵细胞匀浆未引起神经分泌和腺垂体的变化，但导致生精上皮发育周期完成并产生成熟精子。促性腺激素对下丘脑 - 垂体系统的作用通过反馈机制来解释，而无精子发生则是由于雄激素缺乏。卵细胞匀浆作用的结果应与分裂卵细胞DNA的局部刺激作用相关。
