幼儿四价脑膜炎球菌多糖结合白喉疫苗的剂量递增、安全性及免疫原性研究
Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers.
作者信息
Rennels Margaret, King James, Ryall Robert, Manoff Susan, Papa Thomas, Weddle Andrea, Froeschle James
机构信息
Center for Vaccine Development and Department of Pediatrics University of Maryland School of Medicine Baltimore, MD, USA.
出版信息
Pediatr Infect Dis J. 2002 Oct;21(10):978-9. doi: 10.1097/00006454-200210000-00019.
Abstract
Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 microg/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-microg/ml dose appears to be immunologically optimal.
摘要
对30名幼儿注射了两剂与白喉结合的四价（A、C、Y和W-135群）脑膜炎球菌多糖疫苗，各血清群多糖的剂量分别为1、4和10微克/毫升。所有剂量的反应原性均可接受。4微克/毫升的剂量似乎在免疫方面最为理想。
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