Vande Broek I, Stadnik T, Meurs A, Maes J, Van Camp B, Schots R
Department of Medical Oncology and Hematology, Academic Hospital, Free University Brussels (VUB), Belgium.
Leuk Lymphoma. 2002 Aug;43(8):1691-3. doi: 10.1080/1042819021000003054.
We present the case of an 80-year-old male with an history of multiple myeloma (MM) stage I with extramedullary plasmacytoma of the neck, diagnosed 18 months before and in complete remission after radiation therapy and melphalan-prednisone therapy. He was admitted with signs and symptoms characteristic for cavernous sinus syndrome, including diplopia, exophthalmia, ptosis and orbital pain. Magnetic resonance imaging showed a mass lesion in the cavernous sinus, consistent with relapsing extramedullary plasmacytoma. The patient received palliative radiation therapy and high dose dexamethasone, but treatment failed and the patient died. This case represents one of the few reports of extramedullary plasmacytoma of the cavernous sinus. The development of a clinical presentation of cavernous sinus syndrome in a patient with a history of MM or extramedullary plasmacytoma should raise the suspicion of a plasmacytic involvement of the cavernous sinus.
我们报告一例80岁男性患者，有I期多发性骨髓瘤（MM）病史，伴有颈部髓外浆细胞瘤，18个月前确诊，经放射治疗和马法兰-泼尼松治疗后完全缓解。他因海绵窦综合征的典型症状和体征入院，包括复视、眼球突出、上睑下垂和眼眶疼痛。磁共振成像显示海绵窦有一肿块病变，符合复发性髓外浆细胞瘤。患者接受了姑息性放射治疗和大剂量地塞米松治疗，但治疗失败，患者死亡。该病例是海绵窦髓外浆细胞瘤的少数报道之一。有MM或髓外浆细胞瘤病史的患者出现海绵窦综合征的临床表现，应怀疑海绵窦有浆细胞浸润。
