Sasaki K
Hokkaido Igaku Zasshi. 1975 Jul;50(4):397-402.
In dd-mice of both sexes, the thymus, spleen and mesenteric lymph node were morphologically examined after the submandibular gland was extirpated at 35 days of age. When the bilaterally extirpated animals were fed with dried diet pellet which was commonly given to laboratory mice, the body weight decreased rapidly after operation and the thymus and spleen generally atrophied. The atrophy of the lymphatic tissues was especially marked in mice showing a fetal loss of body weight. In the lymphatic tissues, the cortex of the thymus, the follicular area and germinal center of the splenic white pulp, and the cortex of the mesenteric lymph node underwent remarkably atrophic changes. On the other hand, however, when the mice were fed after operation with a liquid diet made of commercial dry pellets, they grow gradually and the thymus, spleen and mesenteric lymph node were almost the same in weight and structure as those in controls. Very recently Martinez-Hernandez, Nakane and Pierce reported that removal of the submandibular gland from mice and rats was followed by loss of body weight and atrophy of the thymus and spleen, and that it caused selective depletion of lymphocytes from the thymus-dependent areas in the peripheral lymphatic tissue. These findings, however, could not be confirmed in the present study.
在35日龄时切除雌雄dd小鼠的下颌下腺后，对其胸腺、脾脏和肠系膜淋巴结进行形态学检查。当给双侧切除下颌下腺的动物喂食通常给实验小鼠的干饲料颗粒时，术后体重迅速下降，胸腺和脾脏普遍萎缩。体重呈胎儿样下降的小鼠，其淋巴组织萎缩尤为明显。在淋巴组织中，胸腺皮质、脾白髓的滤泡区和生发中心以及肠系膜淋巴结皮质均发生明显萎缩性变化。然而，另一方面，当小鼠术后喂食由市售干颗粒制成的流食时，它们逐渐生长，胸腺、脾脏和肠系膜淋巴结的重量和结构与对照组几乎相同。最近，马丁内斯 - 埃尔南德斯、中根和皮尔斯报道，切除小鼠和大鼠的下颌下腺后，体重减轻，胸腺和脾脏萎缩，并且导致外周淋巴组织中胸腺依赖区淋巴细胞选择性耗竭。然而，这些发现本研究中未能得到证实。
