Cornwall G Bryan, Thomas Kevin A, Turner A Simon, Wheeler Donna L, Taylor William R
MacroPore Biosurgery, Inc, San Diego, Calif, USA.
Orthopedics. 2002 Oct;25(10 Suppl):s1167-71. doi: 10.3928/0147-7447-20021002-07.
Iliac crest bone graft harvesting can result in major complications that occur at rates of approximately 6%-8%. The objective of this study was to evaluate the postoperative regeneration of iliac crest donor defects in an animal model after harvesting a full-thickness tricortical graft. In skeletally mature sheep, a tricortical iliac crest graft was harvested. The graft sites were allowed to heal nonprotected or protected with the resorbable polylactic acid sheet material, MacroPore OS Protective Sheeting, (MacroPore Biosurgery, San Diego, Calif). After 6 months of healing, the sites were assessed by examination of undecalcified histologic sections. Histomorphometric measurements of the original defect area, the area of new bone within the defect site, and the percentage of defect filled with new bone were quantified for both control and protected groups. In all histologic sections, new bone growth within the defect sites appeared normal, with no excessive inflammatory cells observed. The developing bone tissue appeared to be remodeling normally. For the nonprotected sites, the area of new bone averaged 16.3 mm2 (+/-7.2 mm2), and the percentage of the defect area filled with bone averaged 10.7% (+/-6.5%). In the protected sites, the area of new bone averaged 64.8 mm2 (+/-11.6 mm2) and the percentage of the defect area filled with bone averaged 25.9% (+/-1.6%). Both differences in area of new bone growth and percentage of defect area filled were statistically significant. Literature review has indicated that regeneration of donor site defects is desirable. Based upon the results of the present study, MacroPore resorbable protective sheeting can improve bone regeneration significantly within the donor site following tricortical iliac crest graft harvesting.
髂嵴取骨可能导致约6%-8%发生率的严重并发症。本研究的目的是在动物模型中评估全层三皮质骨移植后髂嵴供区缺损的术后再生情况。在骨骼成熟的绵羊中，获取三皮质髂嵴移植骨。移植部位不进行保护或用可吸收的聚乳酸片材MacroPore OS Protective Sheeting（MacroPore Biosurgery，加利福尼亚州圣地亚哥）进行保护，使其愈合。愈合6个月后，通过检查未脱钙组织切片对这些部位进行评估。对对照组和保护组的原始缺损面积、缺损部位新骨面积以及新骨填充缺损的百分比进行组织形态计量学测量。在所有组织切片中，缺损部位的新骨生长看起来正常，未观察到过多炎性细胞。发育中的骨组织似乎在正常重塑。对于未保护的部位，新骨面积平均为16.3平方毫米（±7.2平方毫米），骨填充缺损面积的百分比平均为10.7%（±6.5%）。在保护部位，新骨面积平均为64.8平方毫米（±11.6平方毫米），骨填充缺损面积的百分比平均为25.9%（±1.6%）。新骨生长面积和缺损填充百分比的差异均具有统计学意义。文献综述表明供区缺损的再生是可取的。基于本研究结果，MacroPore可吸收保护片材可显著改善三皮质髂嵴移植骨获取后供区内的骨再生。
