Visitsunthorn Nualanong, Moungnoi Pranee, Saengsiriwut Aree, Wacharasindhu Suttipong
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2002 Aug;85 Suppl 2:S599-606.
Long-term inhaled corticosteroids are recommended in persistent asthma in children. The aim of this study was to determine the growth rate of asthmatic Thai children who received long-term inhaled corticosteroids.
This controlled clinical trial was carried out on 145 prepubertal asthmatic Thai children, 81 in the study group (the group who received long-term inhaled corticosteroids) and 64 in the control group.
The mean age of the patients when the study began was 5.9 years in the study group and 4.7 years in the control group. The average dose of inhaled corticosteroids used was 300 microg/day. The average duration overtime of inhaled corticosteroid usage was 2 years (9 months-5 years). The study showed that inhaled corticosteroids (300 microg/day for 9-60 months) have no significant effects on growth rate. From linear regression analysis, the factors that influenced the growth rate of asthmatic patients were the severity of the asthma and the age of the patients when nasal corticosteroids were started. Insulin-like Growth Factor 1 (IGF 1) and Insulin-like Growth Factor Binding Protein 3 (IGFBP 3), were measured in 7 patients in the study group and 5 in the control group. All were normal, the height standard deviation score (Ht.SDS) was below average.
The average dose of inhaled corticosteroids (300 microg/day for 9 months) has no significant effects on the growth rate of prepubertal asthmatic Thai children.
对于儿童持续性哮喘，推荐长期吸入皮质类固醇。本研究的目的是确定接受长期吸入皮质类固醇治疗的泰国哮喘儿童的生长速率。
本对照临床试验对145名青春期前的泰国哮喘儿童进行，研究组81名（接受长期吸入皮质类固醇治疗的组），对照组64名。
研究开始时，研究组患者的平均年龄为5.9岁，对照组为4.7岁。吸入皮质类固醇的平均使用剂量为300微克/天。吸入皮质类固醇的平均使用时长为2年（9个月至5年）。研究表明，吸入皮质类固醇（300微克/天，持续9至60个月）对生长速率无显著影响。通过线性回归分析，影响哮喘患者生长速率的因素是哮喘的严重程度以及开始使用鼻用皮质类固醇时患者的年龄。在研究组的7名患者和对照组的5名患者中测量了胰岛素样生长因子1（IGF 1）和胰岛素样生长因子结合蛋白3（IGFBP 3）。所有结果均正常，身高标准差评分（Ht.SDS）低于平均水平。
吸入皮质类固醇的平均剂量（300微克/天，持续9个月）对青春期前泰国哮喘儿童的生长速率无显著影响。
