Gottlieb Sami L, Douglas John M, Schmid D Scott, Bolan Gail, Iatesta Michael, Malotte C Kevin, Zenilman Jonathan, Foster Mark, Barón Anna E, Steiner John F, Peterman Thomas A, Kamb Mary L
University of Colorado Health Sciences Center and Denver Public Health Department, Denver, Colorado 80204, USA.
J Infect Dis. 2002 Nov 15;186(10):1381-9. doi: 10.1086/344317. Epub 2002 Oct 23.
The seroprevalence of herpes simplex virus type 2 (HSV-2) infection was studied among 4128 patients from sexually transmitted disease (STD) clinics who were enrolled in a randomized controlled trial of human immunodeficiency virus and STD counseling efficacy. HSV-2 seroprevalence was 40.8% and was higher in women than in men (52.0% vs. 32.4%; P<.0001) and higher in blacks than in nonblacks (48.1% vs. 29.6%; P<.0001). Among 14-19-year-old patients, 36.8% of black women and 25.8% of nonblack women were infected with HSV-2. Independent predictors of HSV-2 seropositivity included female sex, black race, older age, less education, more lifetime sex partners, prior diagnosis of syphilis or gonorrhea, and lack of HSV-1 antibody. The majority of HSV-2-seropositive persons (84.7%) had never received a diagnosis of genital herpes. HSV-2 infection is common in STD clinic attendees in the United States, even among young age groups, especially among women. Efforts to prevent genital herpes should begin at an early age. The high rate of undiagnosed HSV-2 infection likely contributes to ongoing transmission.
在4128名来自性传播疾病（STD）诊所的患者中开展了一项研究，这些患者参与了一项关于人类免疫缺陷病毒和性传播疾病咨询疗效的随机对照试验，研究了2型单纯疱疹病毒（HSV-2）感染的血清阳性率。HSV-2血清阳性率为40.8%，女性高于男性（52.0%对32.4%；P<0.0001），黑人高于非黑人（48.1%对29.6%；P<0.0001）。在14 - 19岁的患者中，36.8%的黑人女性和25.8%的非黑人女性感染了HSV-2。HSV-2血清阳性的独立预测因素包括女性、黑人种族、年龄较大、受教育程度较低、一生中有更多性伴侣、既往梅毒或淋病诊断以及缺乏HSV-1抗体。大多数HSV-2血清阳性者（84.7%）从未被诊断为生殖器疱疹。HSV-2感染在美国性传播疾病诊所就诊者中很常见，即使在年轻人群中也是如此，尤其是在女性中。预防生殖器疱疹的努力应从早年开始。HSV-2感染未被诊断的高比例可能导致持续传播。
