对用金硫葡萄糖诱导肥胖的小鼠皮肤中结缔组织大分子的研究。

A study of connective tissue macromolecules in skin of mice with goldthioglucose-induced obesity.

作者信息

Dalferes E R, Radhakrishnamurthy B, Crouch M S, Berenson G S

出版信息

Proc Soc Exp Biol Med. 1975 Mar;148(3):918-24. doi: 10.3181/00379727-148-38660.

Abstract

The effect of obesity on the connective tissue composition of skin was investigated in mice with goldthioglucose (GTG)-induced obesity. Four months after GTG treatment, the obese animals were sacrificed. Acid mucopolysaccharides, glycoproteins, collagen, and elastin were analyzed in the skin and compared to the controls. Total MPS in the skin from obese animals decreased, reflected mostly in hyaluronic acid. Chondroitin showed an increase over controls. The content of soluble glycoproteins varied; total carbohydrate and sialic acid of the glycoprotein tended to increase with obesity. Collagen and elastin both tended to decrease with obesity.

摘要

在注射金硫葡萄糖（GTG）诱导肥胖的小鼠中，研究了肥胖对皮肤结缔组织组成的影响。GTG治疗四个月后，处死肥胖动物。对皮肤中的酸性粘多糖、糖蛋白、胶原蛋白和弹性蛋白进行分析，并与对照组进行比较。肥胖动物皮肤中的总粘多糖减少，主要体现在透明质酸上。软骨素含量比对照组增加。可溶性糖蛋白的含量各不相同；糖蛋白的总碳水化合物和唾液酸含量往往随肥胖程度增加。胶原蛋白和弹性蛋白含量往往随肥胖程度降低。