Zwirner P P, Porsolt R D, Loew D M
Psychopharmacologia. 1975 Dec 31;45(2):133-8. doi: 10.1007/BF00429051.
A new method is described with which the effects of drugs on aggressive behaviour can be compared with their effects on general activity. Two groups of 3 male mice are housed in either half of a macrolon living cage which is divided down the middle by a non-transparent barrier. After 21 days the cage is placed on an activity meter and the dividing wall is removed. The ensuing fighting is scored by an observer and at the same time activity is measured using the activity meter. It was shown that aggression occurred mainly between groups with the dominant members doing most of the fighting. It appeared further that the two parameters measured--aggression and motor activity--respond differentially to the effects of standard psychotropic drugs. By this means it was possible to distinguish between the effects of chlorpromazine, pentobarbitone, chlordiazepoxide and d-amphetamine. In addition it was possible to confirm that an experimental compound, YG 19-256, which in other tests has been shown to inhibit aggressive behaviour without causing general sedation, also has selective anti-aggressive effects in this test. From these results it seems that the intergroup aggression test could well be useful in identifying different classes of psychotropic agents.
本文描述了一种新方法，利用该方法可以将药物对攻击行为的影响与其对一般活动的影响进行比较。将两组各3只雄性小鼠饲养在一个Macrolon居住笼的一半中，笼子中间由一个不透明的隔板隔开。21天后，将笼子放在活动计上，并移除隔板。由一名观察者对随后发生的打斗进行评分，同时使用活动计测量活动情况。结果表明，攻击行为主要发生在组间，占主导地位的成员打斗最为频繁。进一步的研究表明，所测量的两个参数——攻击行为和运动活动——对标准精神药物的反应有所不同。通过这种方法，可以区分氯丙嗪、戊巴比妥、氯氮卓和d-苯丙胺的作用。此外，还可以证实，一种实验化合物YG 19-256，在其他测试中已被证明能抑制攻击行为而不引起全身镇静，在该测试中也具有选择性抗攻击作用。从这些结果来看，组间攻击测试很可能有助于识别不同类别的精神药物。
