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NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.

作者信息

Kavlock Robert, Boekelheide Kim, Chapin Robert, Cunningham Michael, Faustman Elaine, Foster Paul, Golub Mari, Henderson Rogene, Hinberg Irwin, Little Ruth, Seed Jennifer, Shea Katherine, Tabacova Sonia, Tyl Rochelle, Williams Paige, Zacharewski Timothy

机构信息

National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA.

出版信息

Reprod Toxicol. 2002 Sep-Oct;16(5):529-653. doi: 10.1016/s0890-6238(02)00032-1.

DOI:10.1016/s0890-6238(02)00032-1
PMID:12406494
Abstract
摘要

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The inhibition of prostaglandin production during ovulation by exposure to a phthalate mixture is circumvented by cAMP analogue supplementation in a human granulosa cell model.在人颗粒细胞模型中，通过补充环磷酸腺苷（cAMP）类似物可规避因暴露于邻苯二甲酸酯混合物而导致的排卵期间前列腺素生成抑制。
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