[11C]-卡芬太尼与正电子发射断层扫描（PET）所证实的人类脊髓上阿片类物质通路的疼痛激活。

Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET).

作者信息

Bencherif B, Fuchs P N, Sheth R, Dannals R F, Campbell J N, Frost J J

机构信息

Department of Radiology, The Johns Hopkins University School of Medicine, JHOC 3225, 601 N Caroline Street, Baltimore, MD 21287, USA Department of Neurosurgery, The Johns Hopkins University School of Medicine, Meyer 5-109, 600 N Wolfe Street, Baltimore, MD 21287, USA Department of Neurosciences, The Johns Hopkins University School of Medicine, JHOC 3225, 601 N Caroline Street, Baltimore, MD 21287, USA.

出版信息

Pain. 2002 Oct;99(3):589-598. doi: 10.1016/S0304-3959(02)00266-X.

DOI:10.1016/S0304-3959(02)00266-X

PMID:12406535

Abstract

The role of the supraspinal endogenous opioid system in pain processing has been investigated in this study using positron emission tomography imaging of [11C]-carfentanil, a synthetic, highly specific mu opioid receptor (mu-OR) agonist. Eight healthy volunteers were studied during a baseline imaging session and during a session in which subjects experienced pain induced by applying capsaicin topically to the dorsal aspect of the left hand. A pain-related decrease in brain mu-OR binding was observed in the contralateral thalamus consistent with competitive binding between [11C]-carfentanil and acutely released endogenous opioid peptides. This decrease varied directly with ratings of pain intensity. These results suggest that the supraspinal mu-opioid system is activated by acute pain and thus may play a substantial role in pain processing and modulation in pain syndromes.

摘要

在本研究中，利用[11C] - 卡芬太尼（一种合成的、高度特异性的μ阿片受体（mu - OR）激动剂）的正电子发射断层扫描成像，对脊髓上内源性阿片系统在疼痛处理中的作用进行了研究。八名健康志愿者在基线成像阶段以及在左手背局部涂抹辣椒素诱导疼痛的阶段接受了研究。在对侧丘脑中观察到与疼痛相关脑mu - OR结合减少，这与[11C] - 卡芬太尼和急性释放的内源性阿片肽之间的竞争性结合一致。这种减少与疼痛强度评分直接相关。这些结果表明，脊髓上的μ阿片系统被急性疼痛激活，因此可能在疼痛综合征的疼痛处理和调节中发挥重要作用。