Yewdell Jonathan W, Hill Ann B
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Nat Immunol. 2002 Nov;3(11):1019-25. doi: 10.1038/ni1102-1019.
CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral interference with antigen presentation; in particular we consider the importance (and difficulty) of establishing the evolutionary significance (that is, the ability to enhance viral transmission) of viral gene products that interfere with antigen presentation in vitro.
CD8 + T细胞在抗病毒免疫中发挥着重要作用。病毒为阻止病毒感染细胞表面肽 - 主要组织相容性复合体I类复合物的产生或展示而采取的策略演变，证明了这些细胞的重要程度。在这里，我们重点关注病毒对抗抗原呈递的干扰；特别是我们考虑确定体外干扰抗原呈递的病毒基因产物的进化意义（即增强病毒传播的能力）的重要性（和难度）。
