Fennig Shumel, Mottes Amos, Ricter-Levin Gal, Treves Ilan, Levkovitz Yechiel
Shalvata Mental Health Center, Sackler School of Medicine, Tel Aviv University Ramat Aviv, P. O. Box 94, Hod Hasharon, Israel, 45100.
J Nerv Ment Dis. 2002 Oct;190(10):677-82. doi: 10.1097/00005053-200210000-00004.
This study was designed to compare neuropsychological memory measures ("laboratory memory tests") and an everyday memory measure in patients with schizophrenia, patients with major depression, and normal controls. Patients with schizophrenia ( N= 68) treated with typical (N = 33) or atypical ( N= 35) neuroleptics, patients with major depression (N = 30), and a control group (N = 36) were evaluated with clinical measures (Positive and Negative Syndrome Scale and Hamilton Depression Rating Scale), laboratory memory tests (Digit-Span, Paired-Associates, Rey Complex Figure Test, and Digit-Symbol), everyday memory test (RMBT), and the Global Assessment of Functioning (GAF). The schizophrenia group had a significantly lower level of performance in everyday memory and general function but not in laboratory memory tests. Verbal and everyday memory measures were correlated with general function. The diagnosis rather than current symptoms (in remission) contributed to test variance and was correlated with performance on everyday memory and general function tests. Everyday memory and verbal memory were good predictors of general function in schizophrenic and depressive patients in the remitted phase. However, the advantages of these tests over laboratory memory tests need to be further investigated in larger and more representative samples.
本研究旨在比较精神分裂症患者、重度抑郁症患者和正常对照组的神经心理学记忆测量(“实验室记忆测试”)和日常记忆测量。使用典型抗精神病药物(N = 33)或非典型抗精神病药物(N = 35)治疗的精神分裂症患者(N = 68)、重度抑郁症患者(N = 30)和一个对照组(N = 36)接受了临床测量(阳性和阴性症状量表及汉密尔顿抑郁量表)、实验室记忆测试(数字广度、配对联想、雷氏复杂图形测试和数字符号)、日常记忆测试(Rivermead行为记忆测试)以及功能总体评定量表(GAF)评估。精神分裂症组在日常记忆和总体功能方面的表现水平显著较低,但在实验室记忆测试中并非如此。言语和日常记忆测量与总体功能相关。诊断而非当前症状(处于缓解期)导致了测试差异,并且与日常记忆和总体功能测试的表现相关。在缓解期的精神分裂症和抑郁症患者中,日常记忆和言语记忆是总体功能的良好预测指标。然而,这些测试相对于实验室记忆测试的优势需要在更大且更具代表性的样本中进一步研究。