Harlap Susan, Paltiel Ora, Deutsch Lisa, Knaanie Ariella, Masalha Sausan, Tiram Efrat, Caplan Lee S, Malaspina Dolores, Friedlander Yechiel
Department of Obstetrics and Gynecology and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Epidemiology. 2002 Nov;13(6):660-7. doi: 10.1097/00001648-200211000-00010.
Paternal aging is associated with premeiotic damage to spermatogonia, a mechanism by which new point mutations are introduced into the gene pool. We hypothesized that paternal age might contribute to preeclampsia.
We studied the incidence of preeclampsia in 81,213 deliveries surveyed in 1964-1976 in the Jerusalem Perinatal Study. We controlled for maternal age, parity and other risk factors using logistic regression.
Preeclampsia was reported in 1303 deliveries (1.6%). Compared with fathers age 25-34 years, the odds ratios (ORs) for preeclampsia were 1.24 (95% confidence interval = 1.05-1.46) for age 35-44 and 1.80 (1.40-2.31) for age 45+. For fathers age <25, the OR was 1.25 (1.04-1.51). Although weaker than maternal age effects, paternal effects were consistent within subgroups of other variables.
These findings support the hypothesis that a modest proportion of preeclampsia might be explained by new mutations acquired from fathers and add to a growing body of evidence for paternal age effects in birth defects, neuropsychiatric disease and neoplasia.
父亲年龄增加与精原细胞减数分裂前损伤有关，这是一种将新的点突变引入基因库的机制。我们推测父亲年龄可能与子痫前期有关。
我们在耶路撒冷围产期研究中，对1964年至1976年调查的81213例分娩中的子痫前期发病率进行了研究。我们使用逻辑回归控制了母亲年龄、产次和其他风险因素。
1303例分娩（1.6%）报告发生子痫前期。与25至34岁的父亲相比，35至44岁父亲发生子痫前期的比值比（OR）为1.24（95%置信区间=1.05至1.46），45岁及以上父亲为1.80（1.40至2.31）。对于年龄小于25岁的父亲，OR为1.25（1.04至1.51）。尽管父亲年龄的影响比母亲年龄的影响弱，但在其他变量的亚组中，父亲年龄的影响是一致的。
这些发现支持了以下假设，即子痫前期的一小部分可能由从父亲那里获得的新突变来解释，并为父亲年龄对出生缺陷、神经精神疾病和肿瘤形成的影响提供了越来越多的证据。
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