Kapadia Farzana, Vlahov David, Des Jarlais Don C, Strathdee Steffanie A, Ouellet Lawrence, Kerndt Peter, Morse E Edward V, Williams Ian, Garfein Richard S
Center for Urban Epidemiologic Studies, New York Academy of Medicine, NY 10029, USA.
Epidemiology. 2002 Nov;13(6):738-41. doi: 10.1097/00001648-200211000-00023.
Hepatitis C virus (HCV) has emerged as a major public health problem among injection drug users. In this analysis we examine whether disinfection of syringes with bleach has a potentially protective effect on anti-HCV seroconversion.
We conducted a nested case-control study comparing 78 anti-HCV seroconverters with 390 persistently anti-HCV seronegative injection drug users. These data come from the Second Collaborative Injection Drug Users Study, a prospective cohort study that recruited injection drug users from five U.S. cities between 1997 and 1999. We used conditional logistic regression to determine the effect of bleach disinfection of syringes on anti-HCV seroconversion.
Participants who reported using bleach all the time had an odds ratio (OR) for anti-HCV seroconversion of 0.35 (95% confidence interval = 0.08-1.62), whereas those reporting bleach use only some of the time had an odds ratio of 0.76 (0.21-2.70), when compared with those reporting no bleach use.
These results suggest that bleach disinfection of syringes, although not a substitute for use of sterile needles or cessation of injection, may help to prevent HCV infection among injection drug users.
丙型肝炎病毒（HCV）已成为注射吸毒者中的一个主要公共卫生问题。在本分析中，我们研究了用漂白剂对注射器进行消毒是否对丙型肝炎病毒抗体血清阳转有潜在的保护作用。
我们进行了一项巢式病例对照研究，比较了78例丙型肝炎病毒抗体血清阳转者与390例持续丙型肝炎病毒抗体血清阴性的注射吸毒者。这些数据来自第二次注射吸毒者合作研究，这是一项前瞻性队列研究，于1997年至1999年期间从美国五个城市招募注射吸毒者。我们使用条件逻辑回归来确定注射器漂白剂消毒对丙型肝炎病毒抗体血清阳转的影响。
报告一直使用漂白剂的参与者丙型肝炎病毒抗体血清阳转的比值比（OR）为0.35（95%置信区间=0.08-1.62），而与报告未使用漂白剂的参与者相比，报告仅有时使用漂白剂的参与者的比值比为0.76（0.21-2.70）。
这些结果表明，注射器的漂白剂消毒虽然不能替代使用无菌针头或停止注射，但可能有助于预防注射吸毒者中的丙型肝炎病毒感染。
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