乙肝疫苗无应答与HLA基因型/单倍型之间的关系。

The relationship between nonresponse to hepatitis B vaccine and HLA genotype/haplotype.

作者信息

Li Mingyue, Li Rongcheng, Huang Shangzhi, Gong Jian, Zeng Xianjia, Li Yanping, Lu Ming, Li Hui

机构信息

Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2002 May;36(3):180-3.

PMID:12410952

Abstract

OBJECTIVE

To study the relationship between the nonresponse to hepatitis B vaccine and HLA genotype/heplotype in Chinese population and provide the evidence for explaining the genetic mechanism of this nonresponse.

METHODS

Our research focused on the relationship between nonresponse to Hepatitis B vaccine and HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 genotype/haplotype in Chinese population, collected from a community in Guangxi Zhuang Autonomous Region. The group specific amplification was employed to characterize 107 individuals' genotype and haplotype of HLA clusters. Different models statistics such as relative risk test, correlation test and linkage disequilibrium analysis were used to analyze the data.

RESULTS

The results showed that there is a linkage disequilibrium between nonresponse to Hepatitis B vaccine and HLA haplotype DR4, 1122 (DRB1 * 0401- 22, 1122)-DR53 (DRB4 * 0101101, 0102/3)-DQB4 (DQB1 * 04).

CONCLUSION

In Chinese population, nonresponse to hepatitis B vaccine is highly associated with special HLA haplotye.

摘要

目的

研究中国人群中对乙型肝炎疫苗无应答与HLA基因型/单倍型之间的关系，为解释这种无应答的遗传机制提供依据。

方法

我们的研究聚焦于中国人群中对乙型肝炎疫苗无应答与HLA-DRB1、DRB3、DRB4、DRB5和DQB1基因型/单倍型之间的关系，研究对象来自广西壮族自治区的一个社区。采用群体特异性扩增来鉴定107名个体的HLA基因簇基因型和单倍型。使用不同的模型统计方法，如相对风险检验、相关性检验和连锁不平衡分析来分析数据。