Wei Lingge, Wang Changling, Duan Huijun
Department of Ophthalmology, The second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China.
Zhonghua Yan Ke Za Zhi. 2002 Sep;38(9):523-5.
To study dynamically the pathological changes of diabetic retinopathy (DR).
The techniques of light microscopy, immunohistochemical staining, electron microscopy and histochemical electron microscopy were used to quantitatively analyze the Type IV collagen, laminin and their anionic sites in the rat retinal capillary basement membrane (RBM).
RBM became gradually thickened and was accompanied with an increased staining reaction for type IV collagen and laminin and decrease of anionic sites in number.
The increase in thickness, in type IV collagen and laminin and the decrease of the anionic sites in the RBM may be the pathological changes of the exudative lesion in DR.
