大鼠长期给予茶碱后脑内5-羟色胺及杀鼠行为的变化

Changes of brain serotonin and muricide behavior following chronic administration of theophylline in rats.

作者信息

Sakata T, Fuchimoto H, Kodama J, Fukushima M

出版信息

Physiol Behav. 1975 Oct;15(5):449-53. doi: 10.1016/0031-9384(75)90213-9.

Abstract

Temporal modification of amygdaloid serotonin (5HT) content and the resultant muricide behavior, compared to isolated and olfactory bulbectomized rats, were studied after chronic theophylline administration. Theophylline raised amygdaloid 5HT after Day 28 and amygdaloid 5-hydroxyindoleacetic acid (5HIAA), its deaminated metabolite, after Day 7. Theophylline applied for 29 days elevated 5HT and 5HIAA in the amygdala, the diencephalon and the brain stem, but not in the cortex. Effects of theophylline were reduced latency and maintained tendency to kill, even after overnight muricide test. The 5HT content of the amygdala decreased in bulbectomized rats. Discrepancy between brain 5HT changes and aggressive behavior were discussed.

摘要

在长期给予茶碱后，研究了与隔离和嗅球切除大鼠相比，杏仁核5-羟色胺（5HT）含量的时间变化以及由此产生的杀鼠行为。茶碱在第28天后提高了杏仁核5HT水平，在第7天后提高了其脱氨基代谢产物杏仁核5-羟吲哚乙酸（5HIAA）水平。应用29天的茶碱提高了杏仁核、间脑和脑干中的5HT和5HIAA水平，但未提高皮质中的水平。即使经过过夜杀鼠试验，茶碱的作用仍为缩短潜伏期并维持杀鼠倾向。嗅球切除大鼠杏仁核中的5HT含量降低。讨论了大脑5HT变化与攻击行为之间的差异。