Clarkson Thomas B, Anthony Mary S, Mikkola Tomi S, St Clair Richard W
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
Stroke. 2002 Nov;33(11):2700-3. doi: 10.1161/01.str.0000033130.82164.24.
Tibolone is a tissue-specific compound that has favorable effects on bone and menopausal symptoms without stimulating endometrium or breast, but lowers concentrations of plasma high-density lipoprotein (HDL) cholesterol (HDLC). This study was designed to determine whether the HDL lowering with tibolone exacerbated common or internal carotid artery atherosclerosis and to evaluate tibolone treatment relative to conjugated equine estrogens (CEE) alone or in combination with medroxyprogesterone acetate (MPA).
Carotid artery atherosclerosis was compared in groups of surgically postmenopausal cynomolgus monkeys treated with CEE, CEE+MPA, or either of 2 doses of tibolone versus untreated monkeys.
Despite a 30% to 52% lowering of HDLC with tibolone, there was no significant effect on carotid artery atherosclerosis. CEE and CEE+MPA, however, inhibited carotid artery atherosclerosis by approximately 60%.
In surgically postmenopausal cynomolgus monkeys, CEE and CEE+MPA inhibited common and internal carotid artery atherosclerosis. Despite the potentially adverse effects of tibolone on HDLC, tibolone did not exacerbate atherosclerosis.
替勃龙是一种组织特异性化合物，对骨骼和绝经症状有有益作用，不会刺激子宫内膜或乳腺，但会降低血浆高密度脂蛋白（HDL）胆固醇（HDLC）的浓度。本研究旨在确定替勃龙降低HDL是否会加重颈总动脉或颈内动脉粥样硬化，并评估替勃龙相对于单独使用结合马雌激素（CEE）或与醋酸甲羟孕酮（MPA）联合使用时的治疗效果。
将接受CEE、CEE+MPA或两种剂量替勃龙之一治疗的手术绝经后的食蟹猴组与未治疗的猴子组进行颈动脉粥样硬化比较。
尽管替勃龙使HDLC降低了30%至52%，但对颈动脉粥样硬化没有显著影响。然而，CEE和CEE+MPA可使颈动脉粥样硬化抑制约60%。
在手术绝经后的食蟹猴中，CEE和CEE+MPA可抑制颈总动脉和颈内动脉粥样硬化。尽管替勃龙对HDLC可能有不良影响，但替勃龙不会加重动脉粥样硬化。
