Dinsmore A D, Hsu Ming F, Nikolaides M G, Marquez Manuel, Bausch A R, Weitz D A
Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA.
Science. 2002 Nov 1;298(5595):1006-9. doi: 10.1126/science.1074868.
We present an approach to fabricate solid capsules with precise control of size, permeability, mechanical strength, and compatibility. The capsules are fabricated by the self-assembly of colloidal particles onto the interface of emulsion droplets. After the particles are locked together to form elastic shells, the emulsion droplets are transferred to a fresh continuous-phase fluid that is the same as that inside the droplets. The resultant structures, which we call "colloidosomes," are hollow, elastic shells whose permeability and elasticity can be precisely controlled. The generality and robustness of these structures and their potential for cellular immunoisolation are demonstrated by the use of a variety of solvents, particles, and contents.
我们提出了一种制造固体胶囊的方法，可精确控制其尺寸、渗透性、机械强度和兼容性。这些胶囊是通过胶体颗粒在乳液滴界面上的自组装来制造的。在颗粒锁定在一起形成弹性壳后，乳液滴被转移到与液滴内部相同的新鲜连续相流体中。我们将由此产生的结构称为“胶体体”，它是一种中空的弹性壳，其渗透性和弹性可以精确控制。通过使用各种溶剂、颗粒和内容物，证明了这些结构的通用性和稳健性及其在细胞免疫隔离方面的潜力。
