Biragyn Arya, Ruffini Pier Adelchi, Leifer Cynthia A, Klyushnenkova Elena, Shakhov Alexander, Chertov Oleg, Shirakawa Aiko K, Farber Joshua M, Segal David M, Oppenheim Joost J, Kwak Larry W
Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Science. 2002 Nov 1;298(5595):1025-9. doi: 10.1126/science.1075565.
beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.
β-防御素是先天性免疫系统中的小抗菌肽，在黏膜组织和皮肤受到微生物感染时产生。我们证明，小鼠β-防御素2（mDF2β）作为Toll样受体4（TLR-4）的内源性配体直接作用于未成熟树突状细胞，诱导共刺激分子上调和树突状细胞成熟。这些事件进而在体内引发强烈的1型极化适应性免疫反应，表明mDF2β可能在针对病原体以及可能的自身抗原或肿瘤抗原的免疫监视中发挥重要作用。
