Xu Wenhong, Liu Yongge, Wang Sheng, McDonald Todd, Van Eyk Jennifer E, Sidor Agnieszka, O'Rourke Brian
Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Science. 2002 Nov 1;298(5595):1029-33. doi: 10.1126/science.1074360.
Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate-sensitive K+ channel (mitoKATP), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoKCa) of guinea pig ventricular cells. MitoKCa significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoKCa protected hearts against infarction.
线粒体内膜上的离子通道以特定方式影响细胞功能，这些方式可能对细胞存活有害或有益。至少有一种钾（K+）通道，即线粒体三磷酸腺苷敏感性钾通道（mitoKATP），是缺血后保护细胞免受坏死和凋亡损伤的重要效应器。在此，在豚鼠心室细胞的线粒体内膜（mitoKCa）上发现了另一种具有与细胞膜钙激活钾通道相似特性的通道。MitoKCa对心肌细胞的线粒体钾摄取有显著贡献，并且mitoKCa的开放剂可保护心脏免受梗死。
