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[通过关节炎支原体与劳斯氏病毒混合感染在对劳斯氏病毒有抗性的小鼠中诱发白血病]

[Induction of leukemia in Rauscher virus-resistant mice by mixed infection with M. arthritidis and Rauscher virus].

作者信息

Kagan G Ia, Rakovskaia I V, Morgunova T D, Postnikova Z A

出版信息

Vopr Virusol. 1975 Mar-Apr(2):171-6.

PMID:1241177
Abstract

At 2-10 months after combined infection with Rauscher virus and M. arthritidis of mice (C57BL/6XA/He)F1 resistant to this virus 14 out of 23 animals developed leukemia morphologically identical to Rauscher leukemia induced in sensitive mice. In control groups of similar animals infected with virus alone or mycoplasma alone not a single case of leukemia developed. As a result of serial intraperitoneal passages in syngeneic mice of cells of leukemias primarily induced by mixed mycoplasma-virus infection 3 transplantable leukemia strains were obtained the cytological picture of which was similar with the original. Upon intraperitoneal and subcutaneous inoculations of leukemic cells generalized leukemia develops as well as a local transplant under the skin or in the abdominal wall at the site of needle puncture.

摘要

在对这种病毒具有抗性的(C57BL/6XA/He)F1小鼠联合感染劳舍尔病毒和关节炎支原体后2至10个月,23只动物中有14只发生了形态上与敏感小鼠中诱导的劳舍尔白血病相同的白血病。在单独感染病毒或单独感染支原体的相似动物对照组中,未发生一例白血病。通过对主要由支原体 - 病毒混合感染诱导的白血病细胞在同基因小鼠中进行连续腹腔传代,获得了3株可移植的白血病菌株,其细胞学特征与原始菌株相似。对白血细胞进行腹腔和皮下接种后,会发生全身性白血病,同时在针刺部位的皮肤下或腹壁会出现局部移植瘤。

相似文献

1
[Induction of leukemia in Rauscher virus-resistant mice by mixed infection with M. arthritidis and Rauscher virus].[通过关节炎支原体与劳斯氏病毒混合感染在对劳斯氏病毒有抗性的小鼠中诱发白血病]
Vopr Virusol. 1975 Mar-Apr(2):171-6.
2
[Persistence of M. arthritidis and the Rauscher leukemia virus in a mixed Mycoplasma-viral infection in mice].[关节炎支原体和劳氏肉瘤病毒在小鼠支原体 - 病毒混合感染中的持续性]
Vestn Akad Med Nauk SSSR. 1985(3):32-8.
3
[Effect of Mycoplasma arthritidis and Rauscher leukosis virus on murine peritoneal macrophages in vitro and in vivo].
Zh Mikrobiol Epidemiol Immunobiol. 1982 Apr(4):61-5.
4
[Immune response of (C57BL/6xA/Sn)F1 mice in mycoplasm-virus infection].(C57BL/6xA/Sn)F1小鼠在支原体-病毒感染中的免疫反应
Biull Eksp Biol Med. 1979 Sep;88(9):327-9.
5
[Action of Mycoplasma arthritidis and Acholeplasma laidlawii on the immunological reactivity of BALB/C mice infected with the Rauscher leukemia virus].
Nauchnye Doki Vyss Shkoly Biol Nauki. 1979(11):41-4.
6
[Persistence of Rauscher virus in the body of virus-resistant mice infected with this virus and also in leukemia caused by mixed Mycoplasma-viral infection].[劳斯氏病毒在感染该病毒的抗病毒小鼠体内的持续存在以及支原体 - 病毒混合感染所致白血病中的持续存在]
Vestn Akad Med Nauk SSSR. 1976(6):88-94.
7
[Possible mechanism of the resistance of C57Bl/6 mice to a mixed infection with Mycoplasma arthritidis and Rauscher leukemia virus].[C57Bl/6小鼠对关节炎支原体和劳舍尔白血病病毒混合感染产生抗性的可能机制]
Mikrobiol Zh (1978). 1981 Mar-Apr;43(2):199-202.
8
[Reproduction of the Rauscher virus in the body of resistant mice in mono- and mixed Myocplasma-virus infection].[劳氏肉瘤病毒在单核细胞增多症和混合支原体 - 病毒感染的抗性小鼠体内的繁殖]
Vestn Akad Med Nauk SSSR. 1973;28(2):75-9.
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[Role of L-forms of bacteria and mycoplasma in the etiology and pathogenesis of several acute and chronic diseases].[细菌和支原体L型在几种急慢性疾病的病因学和发病机制中的作用]
Vestn Akad Med Nauk SSSR. 1976(5):3-9.
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[Stimulation of hematopoiesis in mice inoculated with Mycoplasma arthritidis].[接种关节炎支原体的小鼠造血功能的刺激]
Zh Mikrobiol Epidemiol Immunobiol. 1980 May(5):72-6.