Hecht K, Hecht T, Poppei M, Treptow K, Hartrodt W, Choinowski S
Acta Biol Med Ger. 1975;34(9):1453-64.
The effect of one single dose of 10 ng Angiotensin II/kg body weight upon affirmed conditional-reflectory response patterns (two-dimensional conditional-reflectory decision process and periodicities of conditional-reflectory processes) was studied in 50 male albino rats in which a neutrotically induced hypertensive blood pressure regulation had been elicited by stress exposure for 135 days. Contrary to healthy animals in which Angiotensin II was demonstrated to act in a biphasic manner, the neurotic animals revealed a monophasic action manifesting itself by a generalized centralnervous excitation. It was noticed, furthermore, that the information processing and regulatory processes of the CNS are considerably disturbed. The chronically hypertensive systolic blood pressure values of neurotic animals, like in healthy ones, show a brief, transient rise immediately following administration of Angiotensin II. These results are not only another proof of a neurotropic component of Angiotensin II action, but they show also that this action allows one to judge the state of disturbed nervous functions. The correlation of the neurotropic effect of Angiotensin II with pathogenetic mechanisms of experimental neurotically induced hypertension is discussed.
在50只雄性白化大鼠中研究了单剂量10 ng血管紧张素II/千克体重对已确认的条件反射反应模式（二维条件反射决策过程和条件反射过程的周期性）的影响，这些大鼠通过135天的应激暴露诱发了神经性高血压血压调节。与已证明血管紧张素II以双相方式起作用的健康动物相反，神经症动物表现出单相作用，表现为全身性中枢神经兴奋。此外，还注意到中枢神经系统的信息处理和调节过程受到了相当大的干扰。与健康动物一样，神经症动物的慢性高血压收缩压值在给予血管紧张素II后立即出现短暂、瞬时的升高。这些结果不仅是血管紧张素II作用的神经otropic成分的又一证据，而且还表明这种作用使人们能够判断神经功能紊乱的状态。讨论了血管紧张素II的神经otropic作用与实验性神经性高血压发病机制的相关性。
