Arai Yukihiro, Handa Tomoyuki, Nakamura Fumihiko, Takahashi Wataru, Maki Kazuhiro, Mitani Kinuko
Department of Hematology, Dokkyo University School of Medicine.
Rinsho Ketsueki. 2002 Sep;43(9):865-7.
A 63-year-old male was diagnosed as chronic myelomonocytic leukemia with normal karyotype in September 1998. He developed acute myelogenous leukemia (AML-M4Eo) in September 2001. The cytogenetic analysis disclosed double t(3;21) at a ratio of 1/20, and the reverse transcriptase-polymerase chain reaction showed AML1/EVI-1 mRNA. He could not achieve complete remission after two courses of induction chemotherapy, and his leukemia cells carrying double t(3;21) were relatively increased. He died of interstitial pneumonia in December 2001. This is the first leukemia case with double t(3;21) and this chromosomal abnormality might play a role in leukemia cell proliferation by generating two AML1/EVI-1 genes.
一名63岁男性于1998年9月被诊断为核型正常的慢性粒单核细胞白血病。2001年9月，他发展为急性髓系白血病（AML-M4Eo）。细胞遗传学分析显示双t(3;21)比例为1/20，逆转录聚合酶链反应显示AML1/EVI-1 mRNA。经过两个疗程的诱导化疗后，他未能达到完全缓解，且携带双t(3;21)的白血病细胞相对增多。他于2001年12月死于间质性肺炎。这是首例双t(3;21)白血病病例，这种染色体异常可能通过产生两个AML1/EVI-1基因在白血病细胞增殖中发挥作用。
