肾上腺素对乙酰胆碱合成、胆碱乙酰化酶及胆碱酯酶活性的影响。

The effect of adrenaline on acetylcholine synthesis, choline acetylase and cholinesterase activity.

作者信息

Górny D, Billewicz-Stankiewicz J, Zajaczkowska M, Kutarski A

出版信息

Acta Physiol Pol. 1975 Jan-Feb;26(1):45-54.

Abstract

The effect of adrenaline on acetylcholine synthesis, choline acetylase and cholinesterase activity. Acta Physiol. Pol. 1975, 26 (1): 45-54. The purpose of the study was to assess the participation of adrenaline in the processes of acetylcholine synthesis and breakdown in white rats. After intraperitoneal administration of adrenaline the content of acetylcholine in the tissues (brain, stomach, sciatic nerve, lumbar spinal cord) initially, slightly decreased, increased in the 30th, 60th, and 120th min, and then fell again below the initial value after 240 min. The rise in acetylcholine tissue content after administration of adrenaline seems to be due to its increased synthesis. This was also confirmed by in vitro investigations. The fall in the tissue acetylcholine content was associated with reduced synthesis of acetylcholine in the cerebral cortex. The increase in acetylcholine synthesis in the brain tissue after adrenaline given in vitro and in vivo does not seem to be caused by activation of choline acetylase. The activity of cholinesterase in the brain was not changed after adrenaline administered in vivo and in vitro.

摘要

肾上腺素对乙酰胆碱合成、胆碱乙酰化酶及胆碱酯酶活性的影响。《波兰生理学杂志》1975年，第26卷第1期：45 - 54页。本研究的目的是评估肾上腺素在大白鼠乙酰胆碱合成与分解过程中的作用。腹腔注射肾上腺素后，组织（脑、胃、坐骨神经、腰脊髓）中乙酰胆碱的含量起初略有下降，在第30、60和120分钟时升高，然后在240分钟后再次降至初始值以下。注射肾上腺素后组织中乙酰胆碱含量的升高似乎是由于其合成增加。体外研究也证实了这一点。组织中乙酰胆碱含量的下降与大脑皮质中乙酰胆碱合成减少有关。体内和体外给予肾上腺素后，脑组织中乙酰胆碱合成的增加似乎并非由胆碱乙酰化酶的激活所致。体内和体外给予肾上腺素后，脑中胆碱酯酶的活性未发生变化。