[鼻息肉上皮细胞中的细胞角蛋白表达]
[Cytokeratin expression in the epithelial cells of nasal polyp].
作者信息
Zhuo Mingying, Yang Jun, Yang Feng, Lin Xing
机构信息
Department of Otolaryngology, Nanping Second Hospital, Jianyang 354200.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Aug;16(8):397-8.
OBJECTIVE
To study the expression of cytokeratin in epithelial cells of nasal polyp and its significance.
METHOD
The monoclonal antibody of AE1, AE3, CK7, CK14, CK19, CK20 were used to determined the corresponding cytokeratin expression in epithelial cells of nasal polyp with immunohistochemical staining.
RESULT
- AE1, CK7, CK19 staining were positive in various pathological epithelium of nasal polyp. AE1, CK19 showed positive in total layer of epithelium. CK7 was positive in goblet cells and basal cells of the pseudostratified epithelium. 2. AE3, CK20 staining were positive in part of simple epithelium and stratified epithelium. 3. AE1, AE3, CK7, CK19 staining showed focal positive in transitional epithelium.
CONCLUSION
CK7, CK19 are the one of the essential assembly type of cytokeratin in epithelium of nasal polyp. During the process of inflammatory reaction, the expression of partial cytokeratin subtype would lose while a new cytokeratin pattern would appear.
目的
研究细胞角蛋白在鼻息肉上皮细胞中的表达及其意义。
方法
采用AE1、AE3、CK7、CK14、CK19、CK20单克隆抗体，通过免疫组化染色检测鼻息肉上皮细胞中相应细胞角蛋白的表达。
结果
- AE1、CK7、CK19染色在鼻息肉各病理类型上皮中均呈阳性。AE1、CK19在上皮全层呈阳性。CK7在假复层上皮的杯状细胞和基底细胞中呈阳性。2. AE3、CK20染色在部分单层上皮和复层上皮中呈阳性。3. AE1、AE3、CK7、CK19染色在移行上皮中呈局灶性阳性。
结论
CK7、CK19是鼻息肉上皮细胞角蛋白的主要组装类型之一。在炎症反应过程中，部分细胞角蛋白亚型的表达会缺失，同时会出现新的细胞角蛋白模式。
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