Karimi M, Rasekhi A R
Haematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Iran.
Haematologia (Budap). 2002;32(2):129-33. doi: 10.1163/156855902320387961.
Iran is a country with high prevalence of about 5-10% of beta-thalassemia trait. The prevalence of Cooly's anemia has declined from 11.6 in 10000 population to 7.2 in 10000 in a five-year period due to screening program of beta-thalassemia trait before marriage. This study was conducted to compare the sensitivity of mean corpuscular hemoglobin (MCH) < 27 pg and mean corpuscular volume (MCV) < 80 fl as a screening test in first step of screening of beta-thalassemia trait. From 2449 couples (4898 cases) participating in the premarital screening to our clinic, 902 cases with either MCH < 27 pg, MCV < 80 fl, anemia, pallor or family history of beta-thalassemia were enrolled in the study. MCV, MCH as well as Hb A2 were measured in all cases. MCH and MCV had sensitivities of 98.5% and 97.6% for the diagnosis of beta-thalassemia trait, respectively. A false negative value of MCH is about 1% lower than that of MCV. MCH is a more sensitive screening test for detecting beta-thalassemia minor before marriage.
伊朗是一个β地中海贫血特征患病率较高的国家，约为5%-10%。由于婚前β地中海贫血特征筛查项目，库利贫血的患病率在五年内从每万人11.6例降至每万人7.2例。本研究旨在比较平均红细胞血红蛋白（MCH）<27 pg和平均红细胞体积（MCV）<80 fl作为β地中海贫血特征筛查第一步筛查试验的敏感性。在我们诊所参与婚前筛查的2449对夫妇（4898例）中，902例MCH<27 pg、MCV<80 fl、贫血、面色苍白或有β地中海贫血家族史的患者被纳入研究。对所有病例测量MCV、MCH以及Hb A2。MCH和MCV对β地中海贫血特征诊断的敏感性分别为98.5%和97.6%。MCH的假阴性值比MCV低约1%。MCH是婚前检测轻型β地中海贫血更敏感的筛查试验。
