Brown Todd T, Dobs Adrian S
Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland 21287, USA.
J Clin Pharmacol. 2002 Nov;42(S1):90S-96S. doi: 10.1002/j.1552-4604.2002.tb06008.x.
In the 35 years since the active compound of marijuana, delta9-tetrahydrocannabinol, was isolated, the psychological and physiological impact of marijuana use has been actively investigated. Animal models have demonstrated that cannabinoid administration acutely alters multiple hormonal systems, including the suppression of the gonadal steroids, growth hormone, prolactin, and thyroid hormone and the activation of the hypothalamic-pituitary-adrenal axis. These effects are mediated by binding to the endogenous cannabinoid receptor in or near the hypothalamus. Despite these findings in animals, the effects in humans have been inconsistent, and discrepancies are likely due in part to the development of tolerance. The long-term consequences of marijuana use in humans on endocrine systems remain unclear.
自大麻的活性成分Δ9-四氢大麻酚被分离出来的35年里，人们一直在积极研究使用大麻对心理和生理的影响。动物模型表明，给予大麻素会急性改变多种激素系统，包括抑制性腺类固醇、生长激素、催乳素和甲状腺激素，以及激活下丘脑-垂体-肾上腺轴。这些作用是通过与下丘脑内或其附近的内源性大麻素受体结合来介导的。尽管在动物身上有这些发现，但在人类身上的影响并不一致，差异可能部分归因于耐受性的产生。大麻对人类内分泌系统的长期影响仍不清楚。
