内源性大麻素与健康和疾病中的内分泌系统。
Endocannabinoids and the Endocrine System in Health and Disease.
作者信息
Hillard Cecilia J
机构信息
Neuroscience Research Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
出版信息
Handb Exp Pharmacol. 2015;231:317-39. doi: 10.1007/978-3-319-20825-1_11.
Abstract
Some of the earliest reports of the effects of cannabis consumption on humans were related to endocrine system changes. In this review, the effects of cannabinoids and the role of the CB1 cannabinoid receptor in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis, prolactin and oxytocin, thyroid hormone and growth hormone, and the hypothalamic-pituitary-adrenal axis. Preclinical and human study results are presented.
摘要
关于大麻消费对人类影响的一些最早报告与内分泌系统变化有关。在本综述中，讨论了大麻素的作用以及CB1大麻素受体在调节以下内分泌系统中的作用：下丘脑 - 垂体 - 性腺轴、催乳素和催产素、甲状腺激素和生长激素，以及下丘脑 - 垂体 - 肾上腺轴。同时展示了临床前和人体研究结果。
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