Jedlicka P
Institute of Pathophysiology, Medical Faculty, Comenius University, Bratislava, Slovakia.
Bratisl Lek Listy. 2002;103(4-5):137-43.
In many regions of the brain, the activity-dependent changes in synaptic strength depend on the frequency and timing of presynaptic stimulation and postsynaptic activity (synaptic plasticity), as well as the history of activity at those synapses (metaplasticity). The Bienenstock, Cooper and Munro (BCM) theory made several assumptions about how synapses modify and these have helped to guide various neurobiological and neurocomputational experiments. There does appear to be a good correspondence of the synaptic plasticity and metaplasticity experimental data with the BCM model. (Fig. 1, Ref. 57.).
在大脑的许多区域，突触强度的活动依赖性变化取决于突触前刺激和突触后活动的频率及时间（突触可塑性），以及这些突触处的活动历史（元可塑性）。比恩斯托克、库珀和蒙罗（BCM）理论对突触如何修饰做出了若干假设，这些假设有助于指导各种神经生物学和神经计算实验。突触可塑性和元可塑性的实验数据与BCM模型之间似乎确实存在良好的对应关系。（图1，参考文献57。）
