脂肪酸去饱和作用：氧化主题的变体
Fatty acid desaturation: variations on an oxidative theme.
作者信息
Behrouzian Behnaz, Buist Peter H
机构信息
Maxygen Inc., 515 Galveston Drive, Redwood City, CA 94063, USA.
出版信息
Curr Opin Chem Biol. 2002 Oct;6(5):577-82. doi: 10.1016/s1367-5931(02)00365-4.
Abstract
Significant progress in our understanding of the mechanism of fatty acid desaturation has been achieved. The site of initial oxidation has been determined for several membrane-bound desaturases and a common cryptoregiochemical theme has been revealed. The results of several studies, including a detailed analysis of a soluble plant desaturase system, point to a close mechanistic relationship between dehydrogenation and hydroxylation pathways.
摘要
我们对脂肪酸去饱和机制的理解取得了重大进展。已经确定了几种膜结合去饱和酶的初始氧化位点，并揭示了一个共同的隐式区域化学主题。包括对可溶性植物去饱和酶系统的详细分析在内的几项研究结果表明，脱氢途径和羟基化途径之间存在密切的机制关系。
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