巨噬细胞激活在癌症治疗中的潜在作用。
A potential role of macrophage activation in the treatment of cancer.
作者信息
Klimp A H, de Vries E G E, Scherphof G L, Daemen T
机构信息
Department of Physiological Chemistry, Faculty of Medical Sciences, Groningen University Institute for Drug Exploration, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
出版信息
Crit Rev Oncol Hematol. 2002 Nov;44(2):143-61. doi: 10.1016/s1040-8428(01)00203-7.
One of the functions of macrophages is to provide a defense mechanism against tumor cells. In the last decades the mechanism of tumor cell killing by macrophages have been studied extensively. The tumor cytotoxic function of macrophages requires stimulation either with bacterial cell wall products such as lipopolysaccharide (LPS) or muramyldipeptide (MDP) or with cytokines such as interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Activated macrophages secrete several substances that are directly involved in tumor cell killing i.e. tumor necrosis factor (TNF) and nitric oxide (NO). On the other hand, substances are secreted that are able to stimulate tumor cell growth, depending on the stage and the nature of the tumor. Several clinical trials have been performed aiming at the activation of macrophages or dendritic cells, a subpopulation of the macrophages. In this review we will summarize and discuss experimental studies and clinical trials based on the activation of macrophages.
巨噬细胞的功能之一是提供针对肿瘤细胞的防御机制。在过去几十年中，巨噬细胞杀伤肿瘤细胞的机制已得到广泛研究。巨噬细胞的肿瘤细胞毒性功能需要用细菌细胞壁产物如脂多糖（LPS）或胞壁酰二肽（MDP），或用细胞因子如干扰素-γ（IFN-γ）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）进行刺激。活化的巨噬细胞分泌几种直接参与肿瘤细胞杀伤的物质，即肿瘤坏死因子（TNF）和一氧化氮（NO）。另一方面，根据肿瘤的阶段和性质，还会分泌能够刺激肿瘤细胞生长的物质。已经进行了几项旨在激活巨噬细胞或树突状细胞（巨噬细胞的一个亚群）的临床试验。在这篇综述中，我们将总结并讨论基于巨噬细胞激活的实验研究和临床试验。
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