Costello Michael F, Horrowitz Stephen, Steigrad Stephen, Saif Najwa, Bennett Michael, Ekangaki Abie
School of Women's and Children's Health, Division of Obstetrics and Gynaecology, University of New South Wales, Royal Hospital for Women, Sydney, New South Wales, Australia.
Fertil Steril. 2002 Nov;78(5):1116-22. doi: 10.1016/s0015-0282(02)03362-9.
To assess whether transcervical intrauterine topical instillation of a local anesthetic agent reduces pain at hysterosalpingography.
Prospective, randomized, double-blind, placebo-controlled study.
Department of reproductive medicine at a university teaching hospital.
PATIENT(S): One hundred ten women undergoing hysterosalpingography (HSG).
INTERVENTION(S): Subjects were randomized to receive either 2 mL of 2% plain lignocaine or 2 mL of 0.9% sodium chloride solution (placebo) topically into the uterine cavity before the HSG was performed.
MAIN OUTCOME MEASURE(S): The degree of lower abdominal pain experienced both during the injection of contrast media at HSG and 10 minutes after the procedure using a 20-cm visual analogue scale (VAS) and a four-point verbal descriptor scale (VDS).
RESULT(S): There was no difference in pain scores between lignocaine and placebo during the HSG. However, at 10 minutes after the HSG, subjects receiving lignocaine experienced more pain than those on placebo.
CONCLUSION(S): Transcervical intrauterine topical instillation of 2 mL of 2% plain lignocaine does not reduce pain during HSG and may lead to increased pain immediately after the procedure.
评估经宫颈子宫内局部注入局部麻醉剂是否能减轻子宫输卵管造影术时的疼痛。
前瞻性、随机、双盲、安慰剂对照研究。
一所大学教学医院的生殖医学科。
110名接受子宫输卵管造影术（HSG）的女性。
在进行HSG之前，将受试者随机分为两组，一组经宫颈子宫内局部注入2ml 2%的普通利多卡因，另一组注入2ml 0.9%的氯化钠溶液（安慰剂）。
使用20厘米视觉模拟量表（VAS）和四点语言描述量表（VDS）评估HSG造影剂注射期间及术后10分钟时的下腹部疼痛程度。
HSG期间，利多卡因组和安慰剂组的疼痛评分无差异。然而，HSG术后10分钟，接受利多卡因的受试者比接受安慰剂的受试者疼痛更明显。
经宫颈子宫内局部注入2ml 2%的普通利多卡因不能减轻HSG期间的疼痛，且可能导致术后即刻疼痛加剧。
