IV型分泌与布鲁氏菌毒力。
Type IV secretion and Brucella virulence.
作者信息
Boschiroli Maria Laura, Ouahrani-Bettache Safia, Foulongne Vincent, Michaux-Charachon Sylvie, Bourg Gisele, Allardet-Servent Annick, Cazevieille Chantal, Lavigne Jean-Phillipe, Liautard Jean Pierre, Ramuz Michel, O'Callaghan David
机构信息
INSERM U431, Faculté de Médecine, Avenue Kennedy, 30900 Nîmes, France.
出版信息
Vet Microbiol. 2002 Dec 20;90(1-4):341-8. doi: 10.1016/s0378-1135(02)00219-5.
The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell endosomal pathways and to create a novel intracellular compartment in which it can replicate.
由virB区域编码的IV型分泌系统是布鲁氏菌的关键毒力因子。该区域的12个基因形成一个操纵子，在吞噬作用后，该操纵子由细胞内吞噬体酸化特异性诱导。我们推测，该系统用于分泌未知的效应分子，这些效应分子使布鲁氏菌能够破坏宿主细胞内体途径，并创建一个新的细胞内区室，使其能够在其中复制。
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