Watanabe Jobu, Sugiura Motoaki, Sato Kazunori, Sato Yuko, Maeda Yasuhiro, Matsue Yoshihiko, Fukuda Hiroshi, Kawashima Ryuta
Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Neuroimage. 2002 Nov;17(3):1207-16. doi: 10.1006/nimg.2002.1198.
One of the important roles of the prefrontal cortex is inhibition of movement. We applied an event-related functional magnetic resonance imaging (fMRI) technique to observe changes in fMRI signals of the entire brain during a GO/NO-GO task to identify the functional fields activated in relation to the NO-GO decision. Eleven normal subjects participated in the study, which consisted of a random series of 30 GO and 30 NO-GO trials. The subjects were instructed to press a mouse button immediately after the GO signal was presented. However, they were instructed not to move when the NO-GO signal was presented. We detected significant changes in MR signals in relation to the preparation phases, GO responses, and NO-GO responses. The activation fields related to the NO-GO responses were located in the bilateral middle frontal cortices, left dorsal premotor area, left posterior intraparietal cortices, and right occipitotemporal area. The fields of activation in relation to the GO responses were found in the left primary sensorimotor, right cerebellar anterior lobule, bilateral thalamus, and the area from the anterior cingulate to the supplementary motor area (SMA). Brain activations related to the preparation phases were identified in the left dorsal premotor, left lateral occipital, right ventral premotor, right fusiform, and the area from the anterior cingulate to the SMA. The results indicate that brain networks consisting of the bilateral prefrontal, intraparietal, and occipitotemporal cortices may play an important role in executing a NO-GO response.
前额叶皮质的重要作用之一是对运动的抑制。我们应用事件相关功能磁共振成像（fMRI）技术，在执行“执行/不执行”任务期间观察全脑fMRI信号的变化，以确定与不执行决策相关的激活功能区。11名正常受试者参与了该研究，研究由30次执行试验和30次不执行试验的随机序列组成。受试者被要求在出现执行信号后立即按下鼠标按钮。然而，当出现不执行信号时，他们被要求不要移动。我们检测到与准备阶段、执行反应和不执行反应相关的磁共振信号有显著变化。与不执行反应相关的激活区位于双侧额中回皮质、左侧背侧运动前区、左侧顶内后皮质和右侧枕颞区。与执行反应相关的激活区见于左侧初级感觉运动区、右侧小脑前叶、双侧丘脑以及从前扣带回至辅助运动区（SMA）的区域。在左侧背侧运动前区、左侧枕外侧、右侧腹侧运动前区、右侧梭状回以及从前扣带回至SMA的区域发现了与准备阶段相关的脑激活。结果表明，由双侧前额叶、顶内和枕颞皮质组成的脑网络可能在执行不执行反应中起重要作用。
