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[囊性纤维化患儿十二指肠液抗原特性的研究(作者译)]

[Study of the antigenic properties of the duodenum juice in children with cystic fibrosis (author's transl)].

作者信息

Bozkowa K, Siwińska-Gołebiowska H, Lambert I

出版信息

Probl Med Wieku Rozwoj. 1975;5:15-22.

PMID:1241440
Abstract

Comparative study of the antigenic properties of the duodenal juice has been carried out; the samples of duodenal juice were collected from the following three groups of children: 1) healthy children 2) children with lambliosis 3) children with cystic fibrosis. The method of double diffusion and precipitation in agar according to Ouchterlony and immunoelectrophoresis technique according to Scheidegger were used. The author's own specific rabbit antisera were applied. On the basis of the results achieved the conclusion may be drawn that the duodenum content of children suffering from cystic fibrosis includes, apart from antigens immunologically identical with the duodenal content of healthy children, also a separate antigen with specific traits for cystic fibrosis. It was also found that a pathological mucoprotein, appearing sporadically in the duodenum juice of children with lambliosis is in no connection with the antigen specific for cystic fibrosis.

摘要

对十二指肠液的抗原特性进行了比较研究;从以下三组儿童中采集十二指肠液样本:1)健康儿童;2)患梨形鞭毛虫病的儿童;3)患囊性纤维化的儿童。采用了根据欧克特洛尼法的琼脂双向扩散和沉淀法以及根据谢德格法的免疫电泳技术。使用了作者自己制备的特异性兔抗血清。根据所取得的结果可以得出结论,患囊性纤维化儿童的十二指肠内容物中,除了有与健康儿童十二指肠内容物免疫相同的抗原外,还有一种具有囊性纤维化特异性特征的单独抗原。还发现,偶尔出现在患梨形鞭毛虫病儿童十二指肠液中的一种病理性粘蛋白与囊性纤维化特异性抗原无关。

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