毒扁豆碱对大鼠行为以及脑内乙酰胆碱和胆碱的影响。
The effect of hemicholinium on behavior and on brain acetylcholine and choline in the rat.
作者信息
Freeman J J, Choi R L, Jenden D J
出版信息
Psychopharmacol Commun. 1975;1(1):15-27.
Behavior and whole brain acetylcholine and choline levels were studied in rats following intraventricular administration of hemicholinium-3. There was an 80% decrease in the content of acetylcholine after 2 hours. The depletion was associated with a decreased turnover of acetylcholine and aggressive behavior. The acetylcholine level did not return to control values until 72 hours after injection, when hemicholinium was still detectable as determined by fluorescence assay. Endogenous choline levels as determined by microwave fixation were 22.7 +/- 1.1 nmol g-1 and were unaffected by hemicholinium; however, hemicholinium caused a significant reduction in the postmortem increase in choline.
在大鼠脑室内注射3-甲基胆碱后，对其行为以及全脑乙酰胆碱和胆碱水平进行了研究。2小时后乙酰胆碱含量下降了80%。这种消耗与乙酰胆碱周转率降低和攻击性行为有关。直到注射后72小时，乙酰胆碱水平才恢复到对照值，此时通过荧光测定法仍可检测到3-甲基胆碱。通过微波固定法测定的内源性胆碱水平为22.7±1.1 nmol g-1，不受3-甲基胆碱影响；然而，3-甲基胆碱导致死后胆碱的增加显著减少。
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