Umhau John C, Petrulis Sarah G, Diaz Rosalyn, Riggs Patti A, Biddison James R, George David T
National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-1610, USA.
Alcohol Alcohol. 2002 Nov-Dec;37(6):586-90. doi: 10.1093/alcalc/37.6.586.
In this study we explored the relationship between alcohol and carbohydrate consumption in long-term abstinent alcoholics.
We employed an established laboratory paradigm which allowed us to stimulate and measure dietary intake. 2-Deoxy-d-glucose (2-DG) is a glucose analogue that causes an intracellular energy deprivation resulting in exaggerated food consumption and a compensatory metabolic response to raise blood glucose. Using a double-blind design, we gave an infusion of 25 mg/kg 2-DG or placebo to 20 long-term abstinent alcoholics and 19 healthy volunteers.
There were no baseline differences in any dietary, behavioural or biochemical variables. As expected, 2-DG increased caloric consumption and blood glucose levels in a time-dependent fashion. There were no differences in food consumption between the alcoholics and the healthy volunteers following the 2-DG stimulus. However, the alcoholic group had a significantly blunted response in blood glucose.
The origin of this atypical blood glucose response may antedate the onset of alcoholism, or it may be secondary to alcohol-related damage that persists beyond 6 months. Previous accounts of increased sweet consumption in alcoholics were not substantiated, although they may be present in the peri-withdrawal period.
在本研究中，我们探讨了长期戒酒的酗酒者酒精摄入与碳水化合物摄入之间的关系。
我们采用了一种既定的实验室范式，使我们能够刺激和测量饮食摄入量。2-脱氧-D-葡萄糖（2-DG）是一种葡萄糖类似物，会导致细胞内能量剥夺，从而导致过度进食和一种补偿性代谢反应以提高血糖。采用双盲设计，我们给20名长期戒酒的酗酒者和19名健康志愿者输注25mg/kg的2-DG或安慰剂。
在任何饮食、行为或生化变量方面，基线均无差异。如预期的那样，2-DG以时间依赖性方式增加热量消耗和血糖水平。在2-DG刺激后，酗酒者和健康志愿者之间的食物摄入量没有差异。然而，酗酒组的血糖反应明显减弱。
这种非典型血糖反应的起源可能早于酗酒的发生，或者可能是6个月后仍持续存在的与酒精相关损伤的继发结果。尽管酗酒者增加甜食消费的情况可能出现在戒断期，但之前的相关报道并未得到证实。
