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本文引用的文献

1
Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis.醌还原酶抑制剂可阻断应激激活蛋白激酶/应激活化蛋白激酶（SAPK/JNK）和核因子κB（NFκB）信号通路，并增强细胞凋亡。
J Biol Chem. 1999 Oct 29;274(44):31150-4. doi: 10.1074/jbc.274.44.31150.
2
Pharmacology of warfarin and clinical implications.
Semin Thromb Hemost. 1999;25(1):13-6. doi: 10.1055/s-2007-996418.
3
Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range.口服抗凝剂：作用机制、临床疗效及最佳治疗范围。
Chest. 1998 Nov;114(5 Suppl):445S-469S. doi: 10.1378/chest.114.5_supplement.445s.
4
Competitive inhibition of HIV-1 protease by warfarin derivatives.华法林衍生物对HIV-1蛋白酶的竞争性抑制作用。
Biochem Biophys Res Commun. 1994 May 30;201(1):290-4. doi: 10.1006/bbrc.1994.1700.
5
Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation.通过IκB-α磷酸化抑制剂对E-选择素、血管细胞黏附分子-1和细胞间黏附分子-1表达的选择性抑制
J Immunol. 1995 Oct 1;155(7):3538-45.
6
Anti-inflammatory effect of warfarin and vitamin K1.华法林与维生素K1的抗炎作用
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jun;307(2):185-90. doi: 10.1007/BF00498462.

香豆素衍生物华法林对炎症信号转导的二分效应。

Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.

作者信息

Kater Arnon P, Peppelenbosch Maikel P, Brandjes Dees P M, Lumbantobing Mika

机构信息

Laboratory for Experimental Internal Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.

出版信息

Clin Diagn Lab Immunol. 2002 Nov;9(6):1396-7. doi: 10.1128/cdli.9.6.1396-1397.2002.

DOI:10.1128/cdli.9.6.1396-1397.2002
PMID:12414784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130100/
Abstract

Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.

摘要

华法林是一种广泛用于预防血栓形成的药物，人们认为它仅通过抑制维生素K依赖性凝血因子起作用。低浓度的华法林可抑制白细胞介素-6的产生和I-κB的磷酸化，但不抑制p38丝裂原活化蛋白激酶的激活。因此，华法林抑制炎症信号转导，这可能有助于其临床疗效。