香豆素衍生物华法林对炎症信号转导的二分效应。
Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.
作者信息
Kater Arnon P, Peppelenbosch Maikel P, Brandjes Dees P M, Lumbantobing Mika
机构信息
Laboratory for Experimental Internal Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.
出版信息
Clin Diagn Lab Immunol. 2002 Nov;9(6):1396-7. doi: 10.1128/cdli.9.6.1396-1397.2002.
Abstract
Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.
摘要
华法林是一种广泛用于预防血栓形成的药物，人们认为它仅通过抑制维生素K依赖性凝血因子起作用。低浓度的华法林可抑制白细胞介素-6的产生和I-κB的磷酸化，但不抑制p38丝裂原活化蛋白激酶的激活。因此，华法林抑制炎症信号转导，这可能有助于其临床疗效。
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