Moffat Scott D, Zonderman Alan B, Metter E Jeffrey, Blackman Marc R, Harman S Mitchell, Resnick Susan M
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging/National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
J Clin Endocrinol Metab. 2002 Nov;87(11):5001-7. doi: 10.1210/jc.2002-020419.
Circulating testosterone (T) levels have behavioral and neurological effects in both human and nonhuman species. Both T concentrations and neuropsychological function decrease substantially with age in men. The purpose of this prospective, longitudinal study was to investigate the relationships between age-associated decreases in endogenous serum T and free T concentrations and declines in neuropsychological performance. Participants were volunteers from the Baltimore Longitudinal Study of Aging, aged 50-91 yr at baseline T assessment. Four hundred seven men were followed for an average of 10 yr, with assessments of multiple cognitive domains and contemporaneous determination of serum total T, SHBG, and a free T index (FTI). We administered neuropsychological tests of verbal and visual memory, mental status, visuomotor scanning and attention, verbal knowledge/language, visuospatial ability, and depressive symptomatology. Higher FTI was associated with better scores on visual and verbal memory, visuospatial functioning, and visuomotor scanning and a reduced rate of longitudinal decline in visual memory. Men classified as hypogonadal had significantly lower scores on measures of memory and visuospatial performance and a faster rate of decline in visual memory. No relations between total T or the FTI and measures of verbal knowledge, mental status, or depressive symptoms were observed. These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men.
循环睾酮（T）水平对人类和非人类物种均具有行为和神经方面的影响。在男性中，T浓度和神经心理功能均会随着年龄的增长而大幅下降。这项前瞻性纵向研究的目的是调查内源性血清T和游离T浓度的年龄相关性下降与神经心理表现下降之间的关系。参与者来自巴尔的摩老年纵向研究的志愿者，在基线T评估时年龄为50 - 91岁。407名男性平均随访10年，对多个认知领域进行评估，并同时测定血清总T、性激素结合球蛋白（SHBG）和游离T指数（FTI）。我们进行了言语和视觉记忆、精神状态、视觉运动扫描和注意力、言语知识/语言、视觉空间能力以及抑郁症状的神经心理测试。较高的FTI与视觉和言语记忆、视觉空间功能、视觉运动扫描方面的更好分数以及视觉记忆纵向下降率降低相关。被归类为性腺功能减退的男性在记忆和视觉空间表现测量方面的得分显著较低，且视觉记忆下降速度更快。未观察到总T或FTI与言语知识、精神状态或抑郁症状测量之间的关系。这些结果表明，循环游离T浓度与老年男性认知表现的特定领域之间可能存在有益关系。
